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Hydrochlorothiazide generic and brand names are available in Europe. Drug Interactions The most common drug interactions are with drugs used to treat asthma or lung conditions such as albuterol, carbamazepine, chlorpromazine, chlorpheniramine, desmopressin, ephedrine hydrochloride, epinephrine-norepinephrine (Norepinephrine-EP) reuptake inhibitors, digoxin, fentanyl, ipratropium, rifampin, sotalol, and tetracycline. Interactions with Medicines Not in List The following medications may interact with nitrobenzapir and phenobarbital hydrobromide: Antidepressants: Anxiolysis drugs (e.g. metoprolol, imipramine) Atropine (Anaphylaxis) Clonidine Cocaine (Tmax) Cholestyramine Clorbutazine Clozapine Dapoxetine Fosamprenavir (Alfixis) Furosemide (Depakene, Prevacid, Pristiq) Irradiating Agents/Nitrogen mustard Lithium Nimodipine Nitrates Nitrous Oxide (O2) Phenobarbital hydrobromide Phenytoin Phenytoin hydrochloride Pregnancy Pregnancy Category C Potential for fetal harm may result from use of nitrobenzapir and phenobarbital hydrobromide. It is best to avoid consuming nitrobenzapir and phenobarbital hydrobromide at any time during pregnancy. Pregnancy Category D: Caution is advisable during pregnancy because of the very rare chance an adverse reaction to phenobarbital hydrobromide and nitrobenzapir. Pregnancy Category D: Caution is advised because of the very rare chance a congenital abnormality in fetus/child during or since the administration of phenobarbital hydrobromide. Pregnancy Category E: Caution in is advised because of the very rare chance an increase in the frequency of seizures a fetus/child resulting from the anticonvulsant effects of phenobarbital hydrobromide. Risk Summary The risk of developing seizures due to its use as a connoted antiarrhythmic in children has not been systematically evaluated. This report does not provide data regarding the occurrence of seizures in pediatric patients treated with nitrobenzapir. Frequency not available Reproduction It is not known if nitrobenzapir and phenobarbital hydrobromide are teratogenic. Reproductive and developmental toxicity studies with nitrobenzapir and phenobarbital hydrobromide in adult pediatric dogs and cats are not available. Aspirin use during pregnancy is contraindicated. Drug-Drug Interactions Antidepressants: Asparagus racemosus, chrysin, diclofenac sodium, gabapentin, indomethacin, propranolol, topiramate, valproic acid, and zolpidem tartrate may affect nitration and cause hypotensive effect. Antipsychotics: Antipsychotics may affect the metabolism of nitrobenzapir and phenobarbital hydrobromide, causing an increase in plasma concentration of the drug and decrease in clearance. addition, some antipsychotics such as olanzapine and risperidone may increase plasma concentrations of phenobarbital hydrobromide resulting in a concomitant rise the plasma concentration. Clinical and serum concentrations of phenobarbital hydrobromide may rise during these therapies, and in some cases clinical or serum concentrations of nitrobenzapir may reach toxic levels. Anxiolysis drugs (e.g. metoprolol, imipramine): may decrease nitration of phenobarbital hydrobromide. A meta-analysis has not been performed.
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